Ontology highlight
ABSTRACT:
SUBMITTER: Kim J
PROVIDER: S-EPMC5581033 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Kim Jeewon J Shin June Ho JH Chen Che-Hong CH Cruz Leslie L Farnebo Lovisa L Yang Jieying J Borges Paula P Kang Gugene G Mochly-Rosen Daria D Sunwoo John B JB
Oncotarget 20170410 32
Chemoresistant cancer cells express high levels of aldehyde dehydrogenases (ALDHs), particularly in head and neck squamous cell carcinoma (HNSCC). The ALDH family of enzymes detoxify both exogenous and endogenous aldehydes. Since many chemotherapeutic agents, such as cisplatin, result in the generation of cytotoxic aldehydes and oxidative stress, we hypothesized that cells expressing high levels of ALDH may be more chemoresistant due to their increased detoxifying capacity and that inhibitors of ...[more]