OVA12 promotes tumor growth by regulating p53 expression in human cancer cells.
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ABSTRACT:
SUBMITTER: Zhang R
PROVIDER: S-EPMC5581076 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Publications
OVA12 promotes tumor growth by regulating p53 expression in human cancer cells.
Zhang Renfeng R Wu Xicai X Xia Xiangfeng X Khanniche Asma A Song Feifei F Zhang Bingchang B Wang Ying Y Ge Hailiang H
Oncotarget 20170428 32
Ovarian cancer-associated antigen 12 (<i>OVA12</i>) was first identified in an ovarian carcinoma complementary DNA (cDNA) expression library and has been shown to play an important role in tumor growth. Here, we found that overexpression of OVA12 accelerated tumor growth in different tumor cells, whereas OVA12 depletion was associated with the opposite effect. Moreover, knocking down OVA12 led to a significant increase in the protein levels of p53, and the overexpression of OVA12 significantly d ...[more]
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