Ontology highlight
ABSTRACT:
SUBMITTER: Wang L
PROVIDER: S-EPMC5581078 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Wang Lingfei L Yu Xiaojie X Wang Chao C Pan Shujun S Liang Beibei B Zhang Yajun Y Chong Xiaodan X Meng Yanchun Y Dong Jian J Zhao Yirong Y Yang Yang Y Wang Huajing H Gao Jie J Wei Huafeng H Zhao Jian J Wang Hao H Hu Chaohua C Xiao Wenze W Li Bohua B
Oncotarget 20170516 32
Trastuzumab, an anti-ErbB2 humanized antibody, brings benefit to patients with ErbB2-amplified metastatic breast cancers. However, the resistance to trastuzumab is common. Our previously reported H2-18, an anti-ErbB2 antibody, potently induced programmed cell death in trastuzumab-resistant breast cancer cells. Here, we aim to investigate the antitumor efficacy of H2-18 in combination with the pan-PI3K inhibitor GDC-0941 in trastuzumab-resistant breast cancer cell lines. The results showed that H ...[more]