The impact of primary tumor location on efficacy of cetuximab in metastatic colorectal cancer patients with different Kras status: a systematic review and meta-analysis.

ABSTRACT:

Objective

To assess the prognostic role of primary tumor location along with Kras status in metastatic colorectal cancer (mCRCs) treated with cetuximab.

Materials and methods

Databases of EMBASE, Pubmed, the Cochrane library, China National Knowledge Infrastructure and other databases from inception to July 2016 were searched. Randomized controlled trial (RCT) and/or retrospective studies of influence of primary tumor location on efficacy of cetuximab in patients with mCRC were identified. The primary endpoint was progression-free survival (PFS), and the secondary endpoints were overall survival (OS), overall response rate (ORR) and disease control rate (DCR).

Results

Ten studies including 2977 cases were finally included. The results of meta-analysis were in favor of

SUBMITTER: Cao DD 

PROVIDER: S-EPMC5581136 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature