Unknown

Dataset Information

0

Significant Locus and Metabolic Genetic Correlations Revealed in Genome-Wide Association Study of Anorexia Nervosa.


ABSTRACT: OBJECTIVE:The authors conducted a genome-wide association study of anorexia nervosa and calculated genetic correlations with a series of psychiatric, educational, and metabolic phenotypes. METHOD:Following uniform quality control and imputation procedures using the 1000 Genomes Project (phase 3) in 12 case-control cohorts comprising 3,495 anorexia nervosa cases and 10,982 controls, the authors performed standard association analysis followed by a meta-analysis across cohorts. Linkage disequilibrium score regression was used to calculate genome-wide common variant heritability (single-nucleotide polymorphism [SNP]-based heritability [h2SNP]), partitioned heritability, and genetic correlations (rg) between anorexia nervosa and 159 other phenotypes. RESULTS:Results were obtained for 10,641,224 SNPs and insertion-deletion variants with minor allele frequencies >1% and imputation quality scores >0.6. The h2SNP of anorexia nervosa was 0.20 (SE=0.02), suggesting that a substantial fraction of the twin-based heritability arises from common genetic variation. The authors identified one genome-wide significant locus on chromosome 12 (rs4622308) in a region harboring a previously reported type 1 diabetes and autoimmune disorder locus. Significant positive genetic correlations were observed between anorexia nervosa and schizophrenia, neuroticism, educational attainment, and high-density lipoprotein cholesterol, and significant negative genetic correlations were observed between anorexia nervosa and body mass index, insulin, glucose, and lipid phenotypes. CONCLUSIONS:Anorexia nervosa is a complex heritable phenotype for which this study has uncovered the first genome-wide significant locus. Anorexia nervosa also has large and significant genetic correlations with both psychiatric phenotypes and metabolic traits. The study results encourage a reconceptualization of this frequently lethal disorder as one with both psychiatric and metabolic etiology.

SUBMITTER: Duncan L 

PROVIDER: S-EPMC5581217 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature

altmetric image

Publications

Significant Locus and Metabolic Genetic Correlations Revealed in Genome-Wide Association Study of Anorexia Nervosa.

Duncan Laramie L   Yilmaz Zeynep Z   Gaspar Helena H   Walters Raymond R   Goldstein Jackie J   Anttila Verneri V   Bulik-Sullivan Brendan B   Ripke Stephan S   Thornton Laura L   Hinney Anke A   Daly Mark M   Sullivan Patrick F PF   Zeggini Eleftheria E   Breen Gerome G   Bulik Cynthia M CM  

The American journal of psychiatry 20170512 9


<h4>Objective</h4>The authors conducted a genome-wide association study of anorexia nervosa and calculated genetic correlations with a series of psychiatric, educational, and metabolic phenotypes.<h4>Method</h4>Following uniform quality control and imputation procedures using the 1000 Genomes Project (phase 3) in 12 case-control cohorts comprising 3,495 anorexia nervosa cases and 10,982 controls, the authors performed standard association analysis followed by a meta-analysis across cohorts. Link  ...[more]

Similar Datasets

| S-EPMC4325090 | biostudies-literature
| S-EPMC5476671 | biostudies-literature
| S-EPMC5845860 | biostudies-literature
2023-08-23 | GSE229316 | GEO
| S-EPMC10474135 | biostudies-literature
| S-EPMC11349005 | biostudies-literature
| S-EPMC8264752 | biostudies-literature
2022-01-31 | GSE186766 | GEO
| S-EPMC8706417 | biostudies-literature
2023-10-31 | GSE245978 | GEO