Ontology highlight
ABSTRACT:
SUBMITTER: Green AM
PROVIDER: S-EPMC5581702 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Green Abby M AM Budagyan Konstantin K Hayer Katharina E KE Reed Morgann A MA Savani Milan R MR Wertheim Gerald B GB Weitzman Matthew D MD
Cancer research 20170627 17
Mutational signatures in cancer genomes have implicated the APOBEC3 cytosine deaminases in oncogenesis, possibly offering a therapeutic vulnerability. Elevated APOBEC3B expression has been detected in solid tumors, but expression of APOBEC3A (A3A) in cancer has not been described to date. Here, we report that A3A is highly expressed in subsets of pediatric and adult acute myelogenous leukemia (AML). We modeled A3A expression in the THP1 AML cell line by introducing an inducible <i>A3A</i> gene. ...[more]