Ontology highlight
ABSTRACT:
SUBMITTER: Pilely K
PROVIDER: S-EPMC5581807 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Frontiers in immunology 20170829
Inflammation is a part of the initial process leading to atherosclerosis and cholesterol crystals (CC), found in atherosclerotic plaques, which are known to induce complement activation. The pentraxins C-reactive protein (CRP), long pentraxin 3 (PTX3), and serum amyloid P component (SAP) are serum proteins associated with increased risk of cardiovascular events and these proteins have been shown to interact with the complement system. Whether the pentraxins binds to CC and mediate downstream com ...[more]