Ontology highlight
ABSTRACT:
SUBMITTER: Hirota T
PROVIDER: S-EPMC5581950 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Hirota Takayuki T Ohta Hiroshi H Powell Benjamin E BE Mahadevaiah Shantha K SK Ojarikre Obah A OA Saitou Mitinori M Turner James M A JMA
Science (New York, N.Y.) 20170817 6354
Having the correct number of chromosomes is vital for normal development and health. Sex chromosome trisomy affects 0.1% of the human population and is associated with infertility. We show that during reprogramming to induced pluripotent stem cells (iPSCs), fibroblasts from sterile trisomic XXY and XYY mice lose the extra sex chromosome through a phenomenon we term trisomy-biased chromosome loss (TCL). Resulting euploid XY iPSCs can be differentiated into the male germ cell lineage and functiona ...[more]