Ontology highlight
ABSTRACT:
SUBMITTER: Soleman S
PROVIDER: S-EPMC5581954 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Soleman Sara S Yip Ping K PK Duricki Denise A DA Moon Lawrence D F LD
Brain : a journal of neurology 20120306 Pt 4
Stroke is the dominant cause of sensorimotor disability that primarily affects the elderly. We now show that neuroplasticity and functional recovery after stroke is constrained by inhibitory chondroitin sulphates. In two blinded, randomized preclinical trials, degradation of chondroitin sulphate using chondroitinase ABC reactivated neuroplasticity and promoted sensorimotor recovery after stroke in elderly rats. Three days after stroke, chondroitinase ABC was microinjected into the cervical spina ...[more]