Ontology highlight
ABSTRACT:
SUBMITTER: Xu Y
PROVIDER: S-EPMC5582416 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Xu Yiming Y Wang Yong Y Yan Siyuan S Zhou Yaqi Y Yang Qiuhua Q Pan Yue Y Zeng Xianqiu X An Xiaofei X Liu Zhiping Z Wang Lina L Xu Jiean J Cao Yapeng Y Fulton David J DJ Weintraub Neal L NL Bagi Zsolt Z Hoda Md Nasrul MN Wang Xiaoling X Li Qinkai Q Hong Mei M Jiang Xuejun X Boison Detlev D Weber Christian C Wu Chaodong C Huo Yuqing Y
EMBO molecular medicine 20170901 9
The nucleoside adenosine is a potent regulator of vascular homeostasis, but it remains unclear how expression or function of the adenosine-metabolizing enzyme adenosine kinase (ADK) and the intracellular adenosine levels influence angiogenesis. We show here that hypoxia lowered the expression of ADK and increased the levels of intracellular adenosine in human endothelial cells. Knockdown (KD) of ADK elevated intracellular adenosine, promoted proliferation, migration, and angiogenic sprouting in ...[more]