Dataset Information

Clinical and Dermoscopic Features of the Scalp in 31 Patients with Dermatomyositis.

ABSTRACT:

Background

Scalp involvement is not directly evaluated in patients with dermatomyositis (DM). Therefore, the exact frequency of scalp dermatomyositis (SDM) and its clinical and trichoscopic characteristics have been poorly described.

Objective

The aim of this study was to determine the frequency and clinical and dermoscopic features of SDM in patients diagnosed with DM.

Methods

We performed a descriptive prospective, cross-sectional observational study that included all patients diagnosed with DM at a Mexican academic institute over the course of a year.

Results

Twenty-four out of 31 patients with DM had scalp involvement at clinical examination, with a prevalence of 77.4%. SDM was clinically characterized by erythema in all cases, scales in 20 (83.3%) patients, nonscarring alopecia in 21 (87.5%) patients, pruritus in 17 (70.8%) patients, and poikiloderma of the scalp in 16 (51.6%) patients. Twenty-eight patients were evaluated by trichoscopy. The most consistent finding was the presence of enlarged capillaries, found in 20 (71.4%) cases, followed by peripilar casts (57.1%) and tufting and interfollicular scales in 14 (50%) cases. Twenty-two patients also had positive nail fold capillaroscopic features similar to those observed by trichoscopy.

Limitations

The simple size was limited.

Conclusions

Scalp involvement and alopecia are common in patients with DM, and trichoscopy shows features similar to those found at capillaroscopy. Trichoscopy is a very important tool for diagnosis of scalp involvement in patients with DM.

SUBMITTER: Jasso-Olivares JC

PROVIDER: S-EPMC5582479 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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Publications

Clinical and Dermoscopic Features of the Scalp in 31 Patients with Dermatomyositis.

Jasso-Olivares Julio C JC Tosti Antonella A Miteva Mariya M Domínguez-Cherit Judith J Díaz-González José M JM

Skin appendage disorders 20170329 3

<h4>Background</h4>Scalp involvement is not directly evaluated in patients with dermatomyositis (DM). Therefore, the exact frequency of scalp dermatomyositis (SDM) and its clinical and trichoscopic characteristics have been poorly described.<h4>Objective</h4>The aim of this study was to determine the frequency and clinical and dermoscopic features of SDM in patients diagnosed with DM.<h4>Methods</h4>We performed a descriptive prospective, cross-sectional observational study that included all pat ...[more]

PMID: 28879187

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Project description:BackgroundSeveral algorithms are available for the dermoscopic diagnosis of pigmented skin lesions. The MC1R gene is a key determinant of pigmentation characteristics that are established host-related melanoma risk factors.ObjectivesTo investigate the association of dermoscopic features of sporadic cutaneous melanomas with clinical characteristics of patients and corresponding tumours and with genetic changes in the MC1R and BRAF genes.MethodsA total of 64 dermoscopic images of 62 patients were scored by ABCD rule and modified pattern analysis. Detailed patients' and melanomas' characteristics were collected. Patients were screened for germline MC1R variants and related melanomas for somatic V600 BRAF mutations.ResultsA lower total dermoscopic score (TDS) was observed in melanomas of patients with red hair (P = 0.019), due to reduced dermoscopic structures (P < 0.0001). Thicker melanomas showed higher TDS values (P = 0.021) due to sharper borders (P < 0.0001) and higher number of colors (P = 0.004). An atypical pigment network was prevalent in superficial spreading melanomas (P = 0.010), in individuals with dark skin (P = 0.043) and hair color (P = 0.001). An atypical vascular pattern was more frequent in nodular (P < 0.0001) and thick (P < 0.0001) melanomas, in individuals with skin type I-II (P = 0.037), blond or red hair color (P = 0.032) and blue or green eyes (P = 0.014). Melanomas of MC1R R carriers showed lower TDS value (P = 0.037), reduced dermoscopic structures (P = 0.001) and lower prevalence of atypical pigment network (P = 0.001). No differences were identified between BRAF-mutated or wild-type melanomas.ConclusionsWe suggest a phenotypic/MC1R profile for melanoma patients and their tumours. Melanomas of MC1R R carriers show a significant lower TDS value, with reduced dermoscopic structures, and a lower prevalence of an atypical pigment network. Non-carriers of MC1R R variants develop melanomas dermoscopically characterized by an atypical pigment network which is prevalent in superficial spreading melanomas, in patients with dark complexion and less frequent in red-haired individuals.

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Dataset Information

Clinical and Dermoscopic Features of the Scalp in 31 Patients with Dermatomyositis.

Background

Objective

Methods

Results

Limitations

Conclusions

Publications

Clinical and Dermoscopic Features of the Scalp in 31 Patients with Dermatomyositis.

Similar Datasets

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