Ontology highlight
ABSTRACT:
SUBMITTER: Wali VB
PROVIDER: S-EPMC5582957 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Wali Vikram B VB Langdon Casey G CG Held Matthew A MA Platt James T JT Patwardhan Gauri A GA Safonov Anton A Aktas Bilge B Pusztai Lajos L Stern David F DF Hatzis Christos C
Cancer research 20161121 2
Triple-negative breast cancer (TNBC) remains an aggressive disease without effective targeted therapies. In this study, we addressed this challenge by testing 128 FDA-approved or investigational drugs as either single agents or in 768 pairwise drug combinations in TNBC cell lines to identify synergistic combinations tractable to clinical translation. Medium-throughput results were scrutinized and extensively analyzed for sensitivity patterns, synergy, anticancer activity, and were validated in l ...[more]