Ontology highlight
ABSTRACT:
SUBMITTER: Snider VG
PROVIDER: S-EPMC5583021 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Snider Victoria G VG Farquhar Erik R ER Allen Mark M Abu-Spetani Ayah A Mukherjee Anusree A
Journal of inorganic biochemistry 20170706
Superoxide plays a key role in cell signaling, but can be cytotoxic within cells unless well regulated by enzymes known as superoxide dismutases (SOD). Nickel superoxide dismutase (NiSOD) catalyzes the disproportion of the harmful superoxide radical into hydrogen peroxide and dioxygen. NiSOD has a unique active site structure that plays an important role in tuning the potential of the nickel center to function as an effective catalyst for superoxide dismutation with diffusion controlled rates. T ...[more]