Ontology highlight
ABSTRACT:
SUBMITTER: Johnsen KB
PROVIDER: S-EPMC5583399 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Johnsen Kasper Bendix KB Burkhart Annette A Melander Fredrik F Kempen Paul Joseph PJ Vejlebo Jonas Bruun JB Siupka Piotr P Nielsen Morten Schallburg MS Andresen Thomas Lars TL Moos Torben T
Scientific reports 20170904 1
Drug delivery to the brain is hampered by the presence of the blood-brain barrier, which excludes most molecules from freely diffusing into the brain, and tightly regulates the active transport mechanisms that ensure sufficient delivery of nutrients to the brain parenchyma. Harnessing the possibility of delivering neuroactive drugs by way of receptors already present on the brain endothelium has been of interest for many years. The transferrin receptor is of special interest since its expression ...[more]