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Experimental infection of dogs with highly pathogenic avian influenza virus (H5N8).

ABSTRACT: During the highly pathogenic avian influenza (HPAI) H5N8 virus outbreak in Korea, a dog in layer farm contaminated by H5N8 was reported seropositive for HPAI H5N8. To investigate the possibility of adaptation and transmission of HPAI H5N8 to dogs, we experimentally inoculated dogs with H5N8. Viral genes were weakly detected in nasal swabs and seroconversions in inoculated and contact dogs. Although the H5N8 virus did not induced severe clinical signs to dogs, the results suggest that surveillance of farm dogs should continue as a species in which the avian influenza virus may acquire infectivity to mammals through frequent contact with the virus.

SUBMITTER: Yuk SS

PROVIDER: S-EPMC5583426 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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Experimental infection of dogs with highly pathogenic avian influenza virus (H5N8).

Yuk Seong-Su SS Lee Dong-Hun DH Park Jae-Keun JK Tseren-Ochir Erdene-Ochir EO Kwon Jung-Hoon JH Noh Jin-Yong JY Song Chang-Seon CS

Journal of veterinary science 20170801 S1

During the highly pathogenic avian influenza (HPAI) H5N8 virus outbreak in Korea, a dog in layer farm contaminated by H5N8 was reported seropositive for HPAI H5N8. To investigate the possibility of adaptation and transmission of HPAI H5N8 to dogs, we experimentally inoculated dogs with H5N8. Viral genes were weakly detected in nasal swabs and seroconversions in inoculated and contact dogs. Although the H5N8 virus did not induced severe clinical signs to dogs, the results suggest that surveillanc ...[more]

PMID: 28385007

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