Unknown

Dataset Information

0

Longitudinal IP-10 Serum Levels Are Associated with the Course of Disease Activity and Remission in Patients with Rheumatoid Arthritis.


ABSTRACT: Although rheumatoid arthritis (RA) is a chronic, persistent autoimmune disease, 10 to 15% of RA patients achieve sustained disease-modifying antirheumatic drug (DMARD)-free remission over time. The biological mechanisms underlying the resolution of persistent inflammation in RA are still unidentified, and there is a lack of prognostic markers. It is well established that increased serum levels of gamma interferon-induced protein 10 (IP-10) are associated with (acute) increased inflammatory responses (e.g., in leprosy). In order to assess the potential of IP-10 as a diagnostic tool for inflammatory episodes of RA, we performed a retrospective study and assessed IP-10 levels in longitudinally banked serum samples obtained from patients upon first diagnosis of RA. The selection consisted of 15 persistent RA patients and 19 patients who achieved DMARD-free sustained remission. IP-10 levels, measured by use of a user-friendly quantitative lateral flow assay (LFA), showed up to 170-fold variation interindividually, and baseline IP-10 levels could not be differentiated between the two patient groups. However, a difference in the change in IP-10 levels between the first and last visits (?IP-10) was observed (P = 0.003) between DMARD-free (median ?IP-10, -662 pg/ml [decrease]) and persistent (median ?IP-10, 468 pg/ml [increase]) RA patients. Moreover, intraindividual changes in IP-10 levels during the course of disease corresponded to the disease activity score (DAS) (P = 0.05). These data indicate that IP-10 is associated with disease activity and perseverance of RA. The association of IP-10 with DAS indicates that this tool may be a practical diagnostic aid to help in monitoring disease progression in RA patients and may also find applications in other chronic diseases with exacerbated inflammatory episodes.

SUBMITTER: van Hooij A 

PROVIDER: S-EPMC5583474 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

altmetric image

Publications

Longitudinal IP-10 Serum Levels Are Associated with the Course of Disease Activity and Remission in Patients with Rheumatoid Arthritis.

van Hooij Anouk A   Boeters Debbie M DM   Tjon Kon Fat Elisa M EM   van den Eeden Susan J F SJF   Corstjens Paul L A M PLAM   van der Helm-van Mil Annette H M AHM   Geluk Annemieke A  

Clinical and vaccine immunology : CVI 20170804 8


Although rheumatoid arthritis (RA) is a chronic, persistent autoimmune disease, 10 to 15% of RA patients achieve sustained disease-modifying antirheumatic drug (DMARD)-free remission over time. The biological mechanisms underlying the resolution of persistent inflammation in RA are still unidentified, and there is a lack of prognostic markers. It is well established that increased serum levels of gamma interferon-induced protein 10 (IP-10) are associated with (acute) increased inflammatory respo  ...[more]

Similar Datasets

| S-EPMC8544781 | biostudies-literature
| S-EPMC9181282 | biostudies-literature
2019-07-12 | GSE122612 | GEO
| S-EPMC8875108 | biostudies-literature
| S-EPMC6277069 | biostudies-literature
| S-EPMC4536238 | biostudies-literature
| S-EPMC8710750 | biostudies-literature
| S-EPMC7313155 | biostudies-literature
| S-EPMC8052358 | biostudies-literature
| S-EPMC4848944 | biostudies-literature