Ontology highlight
ABSTRACT:
SUBMITTER: Knobloch M
PROVIDER: S-EPMC5583518 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Cell reports 20170801 9
Hippocampal neurogenesis is important for certain forms of cognition, and failing neurogenesis has been implicated in neuropsychiatric diseases. The neurogenic capacity of hippocampal neural stem/progenitor cells (NSPCs) depends on a balance between quiescent and proliferative states. Here, we show that the rate of fatty acid oxidation (FAO) regulates the activity of NSPCs. Quiescent NSPCs show high levels of carnitine palmitoyltransferase 1a (Cpt1a)-dependent FAO, which is downregulated in prol ...[more]