Causal relationship between obesity-related traits and TLR4-driven responses at the maternal-fetal interface.
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ABSTRACT:
SUBMITTER: Yang X
PROVIDER: S-EPMC5583648 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Publications
Causal relationship between obesity-related traits and TLR4-driven responses at the maternal-fetal interface.
Yang Xiaohua X Li Ming M Haghiac Maricela M Catalano Patrick M PM O'Tierney-Ginn Perrie P Hauguel-de Mouzon Sylvie S
Diabetologia 20160817 11
<h4>Aims/hypothesis</h4>Obesity triggers complex inflammatory networks within the innate immune system. During pregnancy, the placenta amplifies the low-grade inflammation through activation of Toll-like receptor 4 (TLR4) signalling pathways. The purpose of this study was to investigate the impact of obesity on placental TLR4 expression and inflammatory signals. The secondary aim was to analyse the placental cell type responsible for TLR4 activation.<h4>Methods</h4>Thirty-nine women recruited at ...[more]
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