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6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid attenuates heptatocellular carcinoma in rats with NMR-based metabolic perturbations.


ABSTRACT: AIM:6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid (M1) was synthesized and evaluated for in-vivo antiproliferative action in diethylnitrosamine-induced hepatocarcinogenic rats. MATERIALS & METHODS:The antiproliferative effect of M1 was assessed by various biochemical parameters, histopathology of liver and HPLC analysis. Proton nuclear magnetic resonance-based serum metabolic study was implemented on rat sera to explore the effects of M1 on hepatocellular carcinoma-induced metabolic alterations. RESULTS:M1 showed protective action on liver and restored the arrangement of liver tissues in normal proportion. HPLC analysis displayed a good plasma drug concentration after its oral administration. Score plots of partial least squares discriminate analysis models exhibited that M1 therapy ameliorated hepatocellular carcinoma-induced metabolic alterations which signified its antiproliferative potential. CONCLUSION:M1 manifested notable antiproliferative profile, and warrants further investigation for future anticancer therapy.

SUBMITTER: Kumar P 

PROVIDER: S-EPMC5583658 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid attenuates heptatocellular carcinoma in rats with NMR-based metabolic perturbations.

Kumar Pranesh P   Singh Ashok K AK   Singh Ashok K AK   Raj Vinit V   Rai Amit A   Maity Siddhartha S   Rawat Atul A   Kumar Umesh U   Kumar Dinesh D   Prakash Anand A   Guleria Anupam A   Saha Sudipta S  

Future science OA 20170512 3


<h4>Aim</h4>6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid (M1) was synthesized and evaluated for <i>in-vivo</i> antiproliferative action in diethylnitrosamine-induced hepatocarcinogenic rats.<h4>Materials & methods</h4>The antiproliferative effect of M1 was assessed by various biochemical parameters, histopathology of liver and HPLC analysis. Proton nuclear magnetic resonance-based serum metabolic study was implemented on rat sera to explore the effects of M1 on hepatocellular  ...[more]

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