Ontology highlight
ABSTRACT:
SUBMITTER: Kumar P
PROVIDER: S-EPMC5583658 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Future science OA 20170512 3
<h4>Aim</h4>6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid (M1) was synthesized and evaluated for <i>in-vivo</i> antiproliferative action in diethylnitrosamine-induced hepatocarcinogenic rats.<h4>Materials & methods</h4>The antiproliferative effect of M1 was assessed by various biochemical parameters, histopathology of liver and HPLC analysis. Proton nuclear magnetic resonance-based serum metabolic study was implemented on rat sera to explore the effects of M1 on hepatocellular ...[more]