Ontology highlight
ABSTRACT:
SUBMITTER: Wang JQ
PROVIDER: S-EPMC5584117 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Wang James Q JQ Jeelall Yogesh S YS Humburg Peter P Batchelor Emma L EL Kaya Sarp M SM Yoo Hee Min HM Goodnow Christopher C CC Horikawa Keisuke K
The Journal of experimental medicine 20170712 9
<i>CD79B</i> and <i>MYD88</i> mutations are frequently and simultaneously detected in B cell malignancies. It is not known if these mutations cooperate or how crosstalk occurs. Here we analyze the consequences of <i>CD79B</i> and <i>MYD88<sup>L265P</sup></i> mutations individually and combined in normal activated mouse B lymphocytes. <i>CD79B</i> mutations alone increased surface IgM but did not enhance B cell survival, proliferation, or altered NF-κB responsive markers. Conversely, B cells expr ...[more]