Ontology highlight
ABSTRACT:
SUBMITTER: Cruz-Garcia D
PROVIDER: S-EPMC5584182 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
The Journal of cell biology 20170809 9
The nutrient starvation-specific unconventional secretion of Acb1 in <i>Saccharomyces cerevisiae</i> requires ESCRT-I, -II, and -III and Grh1. In this study, we report that another signal sequence lacking cytoplasmic protein, superoxide dismutase 1 (SOD1), and its mutant form linked to amyotrophic lateral sclerosis (ALS), is also secreted by yeast upon nutrient starvation in a Grh1- and ESCRT-I-, -II-, and -III-dependent process. Our analyses reveal that a conserved diacidic motif (Asp-Glu) in t ...[more]