Ontology highlight
ABSTRACT:
SUBMITTER: Li H
PROVIDER: S-EPMC5584418 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Li Huadong H Deng Yi Y Sun Kang K Yang Haibin H Liu Jie J Wang Meiling M Zhang Zhang Z Lin Jirong J Wu Chuanyue C Wei Zhiyi Z Yu Cong C
Proceedings of the National Academy of Sciences of the United States of America 20170724 35
Kindlins and talins are integrin-binding proteins that are critically involved in integrin activation, an essential process for many fundamental cellular activities including cell-matrix adhesion, migration, and proliferation. As FERM-domain-containing proteins, talins and kindlins, respectively, bind different regions of β-integrin cytoplasmic tails. However, compared with the extensively studied talin, little is known about how kindlins specifically interact with integrins and synergistically ...[more]