Ontology highlight
ABSTRACT:
SUBMITTER: Renvoise E
PROVIDER: S-EPMC5584446 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Renvoisé Elodie E Kavanagh Kathryn D KD Lazzari Vincent V Häkkinen Teemu J TJ Rice Ritva R Pantalacci Sophie S Salazar-Ciudad Isaac I Jernvall Jukka J
Proceedings of the National Academy of Sciences of the United States of America 20170814 35
Much of the basic information about individual organ development comes from studies using model species. Whereas conservation of gene regulatory networks across higher taxa supports generalizations made from a limited number of species, generality of mechanistic inferences remains to be tested in tissue culture systems. Here, using mammalian tooth explants cultured in isolation, we investigate self-regulation of patterning by comparing developing molars of the mouse, the model species of mammali ...[more]