Ontology highlight
ABSTRACT:
SUBMITTER: Mikhailov A
PROVIDER: S-EPMC5584620 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Mikhailov Andrey A Sokolovskaya Alice A Yegutkin Gennady G GG Amdahl Hanne H West Anne A Yagita Hideo H Lahesmaa Riitta R Thompson Linda F LF Jalkanen Sirpa S Blokhin Dmitry D Eriksson John E JE
Journal of immunology (Baltimore, Md. : 1950) 20080701 1
The molecular mechanisms underlying the multiresistant phenotype of leukemic and other cancer cells are incompletely understood. We used expression arrays to reveal differences in the gene expression profiles of an apoptosis-resistant T cell leukemia clone (A4) and normally apoptosis-sensitive parental Jurkat cells. CD73 (ecto-5'-nucleotidase) was the most up-regulated gene in the resistant A4 cell clone. A4 cells displayed CD73 surface expression and significant ecto-5'-nucleotidase activity. T ...[more]