Ontology highlight
ABSTRACT:
SUBMITTER: Li Q
PROVIDER: S-EPMC5584702 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Li Qian Q Wan Jieru J Lan Xi X Han Xiaoning X Wang Zhongyu Z Wang Jian J
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20170523 9
Iron overload plays a key role in the secondary brain damage that develops after intracerebral hemorrhage (ICH). The significant increase in iron deposition is associated with the generation of reactive oxygen species (ROS), which leads to oxidative brain damage. In this study, we examined the protective effects of VK-28, a brain-permeable iron chelator, against hemoglobin toxicity in an ex vivo organotypic hippocampal slice culture (OHSC) model and in middle-aged mice subjected to an in vivo, c ...[more]