Ontology highlight
ABSTRACT:
SUBMITTER: Bassani-Sternberg M
PROVIDER: S-EPMC5584980 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Bassani-Sternberg Michal M Chong Chloé C Guillaume Philippe P Solleder Marthe M Pak HuiSong H Gannon Philippe O PO Kandalaft Lana E LE Coukos George G Gfeller David D
PLoS computational biology 20170823 8
The precise identification of Human Leukocyte Antigen class I (HLA-I) binding motifs plays a central role in our ability to understand and predict (neo-)antigen presentation in infectious diseases and cancer. Here, by exploiting co-occurrence of HLA-I alleles across ten newly generated as well as forty public HLA peptidomics datasets comprising more than 115,000 unique peptides, we show that we can rapidly and accurately identify many HLA-I binding motifs and map them to their corresponding alle ...[more]