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An automated synthesizer for electrochemical 18F-fluorination of organic compounds.

ABSTRACT: Electrochemical 18F-fluorination of organic compounds provides a means to synthesize Positron-Emission-Tomography (PET) tracers difficult to obtain otherwise. Here, the first automated synthesizer that enables radiolabeling through carrier-added electrochemical 18F-fluorination is described. The system provides capabilities for all necessary operations such as drying of cyclotron derived [18F]fluoride, electrochemical incorporation of the radioisotope into a precursor molecule, subsequent reactions such as protecting group removals, HPLC-purification and formulation of the final tracer. Demonstrated is the aliphatic electrochemical 18F-fluorination of methyl 2-(phenylthio)acetate.

SUBMITTER: Waldmann CM

PROVIDER: S-EPMC5585111 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature

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An automated synthesizer for electrochemical 18F-fluorination of organic compounds.

Waldmann Christopher M CM Lebedev Artem A Allison Nathaniel N Sadeghi Saman S

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20170621

Electrochemical 18F-fluorination of organic compounds provides a means to synthesize Positron-Emission-Tomography (PET) tracers difficult to obtain otherwise. Here, the first automated synthesizer that enables radiolabeling through carrier-added electrochemical 18F-fluorination is described. The system provides capabilities for all necessary operations such as drying of cyclotron derived [18F]fluoride, electrochemical incorporation of the radioisotope into a prec ...[more]

PMID: 28662441

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