Ontology highlight
ABSTRACT:
SUBMITTER: Manrique S
PROVIDER: S-EPMC5585231 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Manrique Santiago S Sauter Daniel D Horenkamp Florian A FA Lülf Sebastian S Yu Hangxing H Hotter Dominik D Anand Kanchan K Kirchhoff Frank F Geyer Matthias M
Nature communications 20170905 1
Lentiviral Nefs recruit assembly polypeptide complexes and target sorting motifs in cellular receptors to induce their internalization. While Nef-mediated CD4 downmodulation is conserved, the ability to internalize CD3 was lost in HIV-1 and its precursors. Although both functions play key roles in lentiviral replication and pathogenicity, the underlying structural requirements are poorly defined. Here, we determine the structure of SIV<sub>mac239</sub> Nef bound to the ExxxLM motif of another Ne ...[more]