Ontology highlight
ABSTRACT:
SUBMITTER: Larrimore KE
PROVIDER: S-EPMC5585256 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Larrimore Katherine E KE Kazan I Can IC Kannan Latha L Kendle R Player RP Jamal Tameem T Barcus Matthew M Bolia Ashini A Brimijoin Stephen S Zhan Chang-Guo CG Ozkan S Banu SB Mor Tsafrir S TS
Scientific reports 20170905 1
Butyrylcholinesterase (BChE) is an enzyme with broad substrate and ligand specificities and may function as a generalized bioscavenger by binding and/or hydrolyzing various xenobiotic agents and toxicants, many of which target the central and peripheral nervous systems. Variants of BChE were rationally designed to increase the enzyme's ability to hydrolyze the psychoactive enantiomer of cocaine. These variants were cloned, and then expressed using the magnICON transient expression system in plan ...[more]