Ontology highlight
ABSTRACT:
SUBMITTER: Woods L
PROVIDER: S-EPMC5585348 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Woods Laura L Perez-Garcia Vicente V Kieckbusch Jens J Wang Xiaoqiu X DeMayo Francesco F Colucci Francesco F Hemberger Myriam M
Nature communications 20170905 1
Mammalian reproductive performance declines rapidly with advanced maternal age. This effect is largely attributed to the exponential increase in chromosome segregation errors in the oocyte with age. Yet many pregnancy complications and birth defects that become more frequent in older mothers, in both humans and mice, occur in the absence of karyotypic abnormalities. Here, we report that abnormal embryonic development in aged female mice is associated with severe placentation defects, which resul ...[more]