Ontology highlight
ABSTRACT:
SUBMITTER: Sailland J
PROVIDER: S-EPMC5585359 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Sailland Juliette J Grosche Astrid A Baumlin Nathalie N Dennis John S JS Schmid Andreas A Krick Stefanie S Salathe Matthias M
Scientific reports 20170905 1
Mucociliary clearance (MCC) is a major airway host defence system that is impaired in patients with smoking-associated chronic bronchitis. This dysfunction is partially related to a decrease of airway surface liquid (ASL) volume that is in part regulated by apically expressed cystic fibrosis transmembrane conductance regulator (CFTR) and large-conductance, Ca<sup>2+</sup>-activated, and voltage dependent K<sup>+</sup> (BK) channels. Here, data from human bronchial epithelial cells (HBEC) confirm ...[more]