Unknown

Dataset Information

0

The time-course of cortico-limbic neural responses to air hunger.


ABSTRACT: Several studies have mapped brain regions associated with acute dyspnea perception. However, the time-course of brain activity during sustained dyspnea is unknown. Our objective was to determine the time-course of neural activity when dyspnea is sustained. Eight healthy subjects underwent brain blood oxygen level dependent functional magnetic imaging (BOLD-fMRI) during mechanical ventilation with constant mild hypercapnia (? 45 mm Hg). Subjects rated dyspnea (air hunger) via visual analog scale (VAS). Tidal volume (V(T)) was alternated every 90 s between high VT (0.96 ± 0.23 L) that provided respiratory comfort (12 ± 6% full scale) and low V(T) (0.48 ± 0.08 L) which evoked air hunger (56 ± 11% full scale). BOLD signal was extracted from a priori brain regions and combined with VAS data to determine air hunger related neural time-course. Air hunger onset was associated with BOLD signal increases that followed two distinct temporal profiles within sub-regions of the anterior insula, anterior cingulate and prefrontal cortices (cortico-limbic circuitry): (1) fast, BOLD signal peak <30s and (2) slow, BOLD signal peak >40s. BOLD signal during air hunger offset followed fast and slow temporal profiles symmetrical, but inverse (signal decreases) to the time-courses of air hunger onset. We conclude that differential cortico-limbic circuit elements have unique contributions to dyspnea sensation over time. We suggest that previously unidentified sub-regions are responsible for either the acute awareness or maintenance of dyspnea. These data enhance interpretation of previous studies and inform hypotheses for future dyspnea research.

SUBMITTER: Binks AP 

PROVIDER: S-EPMC5585777 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature

altmetric image

Publications

The time-course of cortico-limbic neural responses to air hunger.

Binks Andrew P AP   Evans Karleyton C KC   Reed Jeffrey D JD   Moosavi Shakeeb H SH   Banzett Robert B RB  

Respiratory physiology & neurobiology 20140927


Several studies have mapped brain regions associated with acute dyspnea perception. However, the time-course of brain activity during sustained dyspnea is unknown. Our objective was to determine the time-course of neural activity when dyspnea is sustained. Eight healthy subjects underwent brain blood oxygen level dependent functional magnetic imaging (BOLD-fMRI) during mechanical ventilation with constant mild hypercapnia (∼ 45 mm Hg). Subjects rated dyspnea (air hunger) via visual analog scale  ...[more]

Similar Datasets

| S-EPMC2776432 | biostudies-literature
2020-12-02 | GSE162419 | GEO
| S-EPMC5928402 | biostudies-literature
| S-EPMC7296844 | biostudies-literature
| S-EPMC6412069 | biostudies-literature
| S-EPMC5739987 | biostudies-literature
| S-EPMC6204483 | biostudies-literature
| S-EPMC6341087 | biostudies-other
| S-EPMC3309531 | biostudies-literature
| S-EPMC7981333 | biostudies-literature