Mucus-Penetrating Nanosuspensions for Enhanced Delivery of Poorly Soluble Drugs to Mucosal Surfaces.
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ABSTRACT:
SUBMITTER: Yu T
PROVIDER: S-EPMC5586074 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Publications
Mucus-Penetrating Nanosuspensions for Enhanced Delivery of Poorly Soluble Drugs to Mucosal Surfaces.
Yu Tao T Chisholm Jane J Choi Woo Jin WJ Anonuevo Abraham A Pulicare Sarah S Zhong Weixi W Chen Minmin M Fridley Colleen C Lai Samuel K SK Ensign Laura M LM Suk Jung Soo JS Hanes Justin J
Advanced healthcare materials 20160926 21
Mucus-penetrating nanosuspensions, consisting of pure hydrophobic therapeutics with dense muco-inert coatings that enable particles to effectively bypass the mucus barrier, demonstrate superior drug distribution and absorption at mucosal surfaces. With significantly increased drug load compared to polymeric systems and established clinical translation of nanosuspensions-based products, mucus-penetrating nanosuspensions are a promising vehicle for improving mucosal delivery of poorly soluble drug ...[more]
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