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A Chlorinating Reagent Yields Vinyl Chlorides with High Regioselectivity under Heterogeneous Gold Catalysis.

ABSTRACT: A novel chlorinating reagent with a high concentration of HCl has enabled the highly regioselective hydrochlorination of unactivated alkynes using a commercial nanogold catalyst. No overchlorination or hydration products were formed, and various functional groups were tolerated. This hydrochlorination method could be conducted under open air.

SUBMITTER: Liang S

PROVIDER: S-EPMC5586251 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature

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A Chlorinating Reagent Yields Vinyl Chlorides with High Regioselectivity under Heterogeneous Gold Catalysis.

Liang Shengzong S Ebule Rene R Hammond Gerald B GB Xu Bo B

Organic letters 20170815 17

A novel chlorinating reagent with a high concentration of HCl has enabled the highly regioselective hydrochlorination of unactivated alkynes using a commercial nanogold catalyst. No overchlorination or hydration products were formed, and various functional groups were tolerated. This hydrochlorination method could be conducted under open air. ...[more]

PMID: 28809497

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