Ontology highlight
ABSTRACT:
SUBMITTER: Ferretti L
PROVIDER: S-EPMC5586374 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Ferretti Luca L Ledda Alice A Wiehe Thomas T Achaz Guillaume G Ramos-Onsins Sebastian E SE
Genetics 20170705 1
We investigate the dependence of the site frequency spectrum on the topological structure of genealogical trees. We show that basic population genetic statistics, for instance, estimators of <i>θ</i> or neutrality tests such as Tajima's <i>D</i>, can be decomposed into components of waiting times between coalescent events and of tree topology. Our results clarify the relative impact of the two components on these statistics. We provide a rigorous interpretation of positive or negative values of ...[more]