Ontology highlight
ABSTRACT:
SUBMITTER: Ramstetter MD
PROVIDER: S-EPMC5586387 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Ramstetter Monica D MD Dyer Thomas D TD Lehman Donna M DM Curran Joanne E JE Duggirala Ravindranath R Blangero John J Mezey Jason G JG Williams Amy L AL
Genetics 20170724 1
Inferring relatedness from genomic data is an essential component of genetic association studies, population genetics, forensics, and genealogy. While numerous methods exist for inferring relatedness, thorough evaluation of these approaches in real data has been lacking. Here, we report an assessment of 12 state-of-the-art pairwise relatedness inference methods using a data set with 2485 individuals contained in several large pedigrees that span up to six generations. We find that all methods ha ...[more]