Ontology highlight
ABSTRACT:
SUBMITTER: Semba Y
PROVIDER: S-EPMC5587750 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Semba Yuichiro Y Harada Akihito A Maehara Kazumitsu K Oki Shinya S Meno Chikara C Ueda Jun J Yamagata Kazuo K Suzuki Atsushi A Onimaru Mitsuho M Nogami Jumpei J Okada Seiji S Akashi Koichi K Ohkawa Yasuyuki Y
Nucleic acids research 20170901 15
Chromatin reorganization is necessary for pluripotent stem cells, including embryonic stem cells (ESCs), to acquire lineage potential. However, it remains unclear how ESCs maintain their characteristic chromatin state for appropriate gene expression upon differentiation. Here, we demonstrate that chromodomain helicase DNA-binding domain 2 (Chd2) is required to maintain the differentiation potential of mouse ESCs. Chd2-depleted ESCs showed suppressed expression of developmentally regulated genes ...[more]