Ontology highlight
ABSTRACT:
SUBMITTER: Niki M
PROVIDER: S-EPMC5587792 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Niki Masanori M Nakajima Kohei K Ishikawa Daichi D Nishida Jun J Ishifune Chieko C Tsukumo Shin-Ichi SI Shimada Mitsuo M Nagahiro Shinji S Mitamura Yoshinori Y Yasutomo Koji K
Scientific reports 20170906 1
MicroRNAs have broad roles in tumorigenesis and cell differentiation through regulation of target genes. Notch signaling also controls cell differentiation and tumorigenesis. However, the mechanisms through which Notch mediates microRNA expression are still unclear. In this study, we aimed to identify microRNAs regulated by Notch signaling. Our analysis found that microRNA-449a (miR-449a) was indirectly regulated by Notch signaling. Although miR-449a-deficient mice did not show any Notch-depende ...[more]