Ontology highlight
ABSTRACT:
SUBMITTER: Huang C
PROVIDER: S-EPMC5587809 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Huang Chunliu C Shi Junjie J Guo Yibin Y Huang Weijun W Huang Shanshan S Ming Siqi S Wu Xingui X Zhang Rui R Ding Junjun J Zhao Wei W Jia Jie J Huang Xi X Xiang Andy Peng AP Shi Yongsheng Y Yao Chengguo C
Nucleic acids research 20170901 15
mRNA 3' end processing is an essential step in gene expression. It is well established that canonical eukaryotic pre-mRNA 3' processing is carried out within a macromolecular machinery consisting of dozens of trans-acting proteins. However, it is unknown whether RNAs play any role in this process. Unexpectedly, we found that a subset of small nucleolar RNAs (snoRNAs) are associated with the mammalian mRNA 3' processing complex. These snoRNAs primarily interact with Fip1, a component of cleavage ...[more]