Mettl3-mediated m6A regulates spermatogonial differentiation and meiosis initiation.
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ABSTRACT:
SUBMITTER: Xu K
PROVIDER: S-EPMC5587845 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Publications
Mettl3-mediated m<sup>6</sup>A regulates spermatogonial differentiation and meiosis initiation.
Xu Kai K Yang Ying Y Feng Gui-Hai GH Sun Bao-Fa BF Chen Jun-Qing JQ Li Yu-Fei YF Chen Yu-Sheng YS Zhang Xin-Xin XX Wang Chen-Xin CX Jiang Li-Yuan LY Liu Chao C Zhang Ze-Yu ZY Wang Xiu-Jie XJ Zhou Qi Q Yang Yun-Gui YG Li Wei W
Cell research 20170815 9
METTL3 catalyzes the formation of N<sup>6</sup>-methyl-adenosine (m<sup>6</sup>A) which has important roles in regulating various biological processes. However, the in vivo function of Mettl3 remains largely unknown in mammals. Here we generated germ cell-specific Mettl3 knockout mice and demonstrated that Mettl3 was essential for male fertility and spermatogenesis. The ablation of Mettl3 in germ cells severely inhibited spermatogonial differentiation and blocked the initiation of meiosis. Trans ...[more]
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