Ontology highlight
ABSTRACT:
SUBMITTER: Bustos-Moran E
PROVIDER: S-EPMC5589067 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Bustos-Morán Eugenio E Blas-Rus Noelia N Martin-Cófreces Noa Beatriz NB Sánchez-Madrid Francisco F
Journal of cell science 20170216 7
The immune synapse (IS) is a specialized structure formed at the contact area between T lymphocytes and antigen-presenting cells (APCs) that is essential for the adaptive immune response. Proper T cell activation requires its polarization towards the APC, which is highly dependent on the tubulin cytoskeleton. Microtubule-associated protein-4 (MAP4) is a microtubule (MT)-stabilizing protein that controls MTs in physiological processes, such as cell division, migration, vesicular transport or prim ...[more]