Ontology highlight
ABSTRACT:
SUBMITTER: Huang W
PROVIDER: S-EPMC5589553 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Huang Wenqiang W Guo Weiwei W You Xue X Pan Yi Y Dong Zhenyang Z Jia Gaozhen G Yang Chenghua C Chen Yan Y
Oncotarget 20160603 33
As a newly discovered tumor suppressor, the potential function of PAQR3 in human prostate cancer has not been demonstrated. In this study, we report that PAQR3 is able to inhibit the growth and migration of human prostate cancer cells both <i>in vitro</i> and <i>in vivo</i>. Overexpression of PAQR3 inhibits the proliferation of PC3 and DU145 cells by both MTT and colony formation assays. Consistently, knockdown of PAQR3 enhances the proliferation of these cells. In wound-healing and transwell as ...[more]