Ontology highlight
ABSTRACT:
SUBMITTER: Liu J
PROVIDER: S-EPMC5589576 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Oncotarget 20170420 33
Despite intensive efforts in the search for small molecules with anti-cancer activity, it remains challenging to achieve both high effectiveness and safety, since many agents lack the selectivity to only act on cancer cells. The interface of two apoptotic proteins, myeloid cell leukemia-1 (Mcl-1) and p53 upregulated modulator of apoptosis (PUMA), has been recently affirmed as a target for treating cancers, as the disruption of Mcl-1-PUMA binding can reduce cancer cell survival and protect normal ...[more]