Cell-cycle arrest biomarkers in urine to predict acute kidney injury in septic and non-septic critically ill patients.

ABSTRACT:

Purpose

To analyse the usefulness of the composite index of the tissue inhibitor of metalloproteinases-2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7) as urinary biomarkers for the early prediction of AKI in septic and non-septic patients.

Methods

This is a prospective, observational study including patients admitted to ICU from acute care departments and hospital length of stay <48 h. The main exclusion criteria were pre-existing eGFR <30 mL/min/1.73 m² and hospitalisation 2 months prior to current admission. The [TIMP-2]·[IGFBP7] index was analysed twice, within the first 12 h of ICU admission.

Results

The sample included 98 patients. AKI incidence during ICU stay was 50%. Sepsis was diagnosed in 40.8%. Baseline renal variables were c

SUBMITTER: Cuartero M 

PROVIDER: S-EPMC5589717 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature