Ontology highlight
ABSTRACT:
SUBMITTER: Vader MJC
PROVIDER: S-EPMC5590000 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Vader M J C MJC Madigan M C MC Versluis M M Suleiman H M HM Gezgin G G Gruis N A NA Out-Luiting J J JJ Bergman W W Verdijk R M RM Jager M J MJ van der Velden P A PA
British journal of cancer 20170815 6
<h4>Background</h4>Mutations in GNAQ/11 genes are considered an early event in the development of uveal melanoma that may derive from a pre-existing nevus. The Hippo pathway, by way of YAP activation, rather than MAP kinase, has a role in the oncogenic capacity of GNAQ/11 mutations.<h4>Methods</h4>We investigated 16 nevi from 13 human eyes for driver GNAQ/11 mutations using droplet digital PCR and determined whether nevi are clonal by quantifying mutant nevus cell fractions. Immunohistochemistry ...[more]