Ontology highlight
ABSTRACT:
SUBMITTER: Slutter B
PROVIDER: S-EPMC5590757 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Slütter Bram B Van Braeckel-Budimir Natalija N Abboud Georges G Varga Steven M SM Salek-Ardakani Shahram S Harty John T JT
Science immunology 20170106 7
Lung-resident memory CD8 T cells (T<sub>RM</sub>) induced by influenza A virus (IAV) that are pivotal for providing subtype-transcending protection against IAV infection (heterosubtypic immunity) are not maintained long term, causing gradual loss of protection. The short-lived nature of lung T<sub>RM</sub> contrasts sharply with long-term maintenance of T<sub>RM</sub> induced by localized infections in the skin and in other tissues. We show that the decline in lung T<sub>RM</sub> is determined b ...[more]