Ontology highlight
ABSTRACT:
SUBMITTER: Lim CJ
PROVIDER: S-EPMC5590795 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Lim Chae Jin CJ Lee Yong-Moon YM Kang Seung Goo SG Lim Hyung W HW Shin Kyong-Oh KO Jeong Se Kyoo SK Huh Yang Hoon YH Choi Suin S Kor Myungho M Seo Ho Seong HS Park Byeong Deog BD Park Keedon K Ahn Jeong Keun JK Uchida Yoshikazu Y Park Kyungho K
Biomolecules & therapeutics 20170901 5
Ultraviolet (UV) irradiation is a relevant environment factor to induce cellular senescence and photoaging. Both autophagy- and silent information regulator T1 (SIRT1)-dependent pathways are critical cellular processes of not only maintaining normal cellular functions, but also protecting cellular senescence in skin exposed to UV irradiation. In the present studies, we investigated whether modulation of autophagy induction using a novel synthetic SIRT1 activator, heptasodium hexacarboxymethyl di ...[more]