Ontology highlight
ABSTRACT:
SUBMITTER: Alam N
PROVIDER: S-EPMC5590822 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Structure (London, England : 1993) 20160301 3
HDAC8 is a member of the family of histone deacetylases (HDACs) that catalyze the deacetylation of acetyl lysine residues within histone and non-histone proteins. The recent identification of novel non-histone HDAC8 substrates such as SMC3, ERRα, and ARID1A indicates a complex functionality of this enzyme in cellular homeostasis. To discover additional HDAC8 substrates, we developed a comprehensive, structure-based approach based on Rosetta FlexPepBind, a protocol that evaluates peptide-binding ...[more]