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Quality improvement of surface triangular mesh using a modified Laplacian smoothing approach avoiding intersection.

ABSTRACT: We present a systematic procedure to improve the qualities of triangular molecular surface meshes and at the same time preserve the manifoldness. The procedure utilizes an algorithm to remove redundant points having three or four valences and another algorithm to smooth the mesh using a modified version of Laplacian method without causing intersecting triangles. This approach can be effectively applied to any manifold surface meshes with arbitrary complex geometry. In this paper, the tested meshes are biomolecular surface meshes exhibiting typically highly irregular geometry. The results show that the qualities of the surface meshes are greatly improved and the manifoldness of the surface meshes are preserved. Compared with the original meshes, these improved molecular surface meshes can be directly applied to boundary element simulations and generation of body-fitted volume meshes using Tetgen. The procedure has been incorporated into our triangular molecular surface mesh generator, TMSmesh 2.0. It can be also used as a standalone program and works together with any other surface triangular mesh generator to obtain qualified manifold mesh. The package is downloadable at https://doi.org/10.6084/m9.figshare.5346169.v1 and can be run online at http://www.xyzgate.com.

SUBMITTER: Liu T

PROVIDER: S-EPMC5590917 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Quality improvement of surface triangular mesh using a modified Laplacian smoothing approach avoiding intersection.

Liu Tiantian T Chen Minxin M Song Yu Y Li Hongliang H Lu Benzhuo B

PloS one 20170908 9

We present a systematic procedure to improve the qualities of triangular molecular surface meshes and at the same time preserve the manifoldness. The procedure utilizes an algorithm to remove redundant points having three or four valences and another algorithm to smooth the mesh using a modified version of Laplacian method without causing intersecting triangles. This approach can be effectively applied to any manifold surface meshes with arbitrary complex geometry. In this paper, the tested mesh ...[more]

PMID: 28886110

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Project description:BackgroundAlthough new evidence-based practices are frequently implemented in clinical settings, many are not sustained, limiting the intended impact. Within implementation science, there is a gap in understanding sustainability. Pediatric healthcare settings have a robust history of quality improvement (QI), which includes a focus on continuation of change efforts. QI capability and sustainability capacity, therefore, serve as a useful concept for connecting the broader fields of QI and implementation science to provide insights on improving care. This study addresses these gaps in understanding of sustainability in pediatric settings and its relationship to QI.MethodsThis is a cross-sectional observational study conducted within pediatric academic medical centers in the United States. Clinicians surveyed worked with one of three evidence-based clinical programs: perioperative antimicrobial stewardship prescribing, early mobility in the intensive care unit, and massive blood transfusion administration. Participants completed two assessments: (1) the Clinical Sustainability Assessment Tool (CSAT) and (2) a 19-question assessment that included demographics and validation questions, specifically a subset of questions from the Change Process Capability Questionnaire, a QI scale. Initial descriptive and bivariate analyses were conducted prior to building mixed-effects models relating perceived QI to clinical sustainability capacity.ResultsA total of 181 individuals from three different programs and 30 sites were included in the final analyses. QI capability scores were assessed as a single construct (5-point Likert scale), with an average response of 4.16 (higher scores indicate greater QI capability). The overall CSAT score (7-point Likert scale) was the highest for massive transfusion programs (5.51, SD = 0.91), followed by early mobility (5.25, SD = 0.92) and perioperative antibiotic prescribing (4.91, SD = 1.07). Mixed-effects modeling illustrated that after controlling for person and setting level variables, higher perceptions of QI capabilities were significantly related to overall clinical sustainability.ConclusionOrganizations and programs with higher QI capabilities had a higher sustainability capacity, even when controlling for differences at the individual and intervention levels. Organizational factors that enable evidence-based interventions should be further studied, especially as they relate to sustainability. Issues to be considered by practitioners when planning for sustainability include bedside provider perceptions, intervention achievability, frequency of delivery, and organizational influences.

Project description:Various materials and approaches have been used to optimize the biocompatibility of mesh to reduce the implant-induced host response in intraperitoneal onlay mesh (IPOM) repair. Ineffective host integration, limited resistance to contamination, and untargeted administration hinder the wider application of the currently available clinical options. In this study, human amniotic membrane (HAM) was decellularized, fully characterized, and compared with porcine small intestinal submucosa (SIS) in terms of its structure, components, and bioactivity. In an in vivo study, HAM was reinforced with silk fibroin (SF) membrane, which was fabricated as a biodegradable submicroscale template by electrospinning, to construct a bilayer composite mesh. The independent SF membrane, associated with HAM and SIS, was evaluated for tissue remodeling in vitro. The HAM-SF and SIS meshes were then characterized morphologically and implanted intraperitoneally into Sprague-Dawley rats for 28 days for macroscopic investigation of their integration into the host via interactions of regulatory factors. After decellularization, HAM formed a bioagent-rich collagen-based acellular structure. HAM was superior to SIS in concurrently suppressing the expression of transforming growth factor ?1 (TGF-?1) and proangiogenic proliferation. When HAM, SF, and SIS were used as regenerative scaffolds, they showed qualified biocompatibility, cell infiltration, and degradation in vitro. Comparatively, macroscopic observation after implantation indicated that HAM-SF induced less-intensive intraperitoneal adhesion and weaker inflammatory responses at the interface but greater angiogenesis in the explant than SIS. Analysis of the expression of regulatory factors showed a greater quantity of hepatocyte growth factor (HGF) in HAM, which partly inhibited the expression of TGF-?1 and promoted vascular endothelial growth factor (VEGF)-induced angiogenesis. This bioactive interaction appeared to be responsible for the better host integration, making HAM more biocompatible than SIS in IPOM repair. When combined with SF, HAM displayed similar mechanical properties to SIS. In conclusion, HAM displayed better bioactivity and biocompatibility than SIS. After its reinforcement with SF, HAM-SF is a promising biocomposite mesh for IPOM repair.

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Quality improvement of surface triangular mesh using a modified Laplacian smoothing approach avoiding intersection.

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Quality improvement of surface triangular mesh using a modified Laplacian smoothing approach avoiding intersection.

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