Ontology highlight
ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC5591163 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Wang Yuan Y Li Xiuling X Gao Yaoyu Y Li Zhi Z Yu Lidong L Meng Qingbo Q Sun Li L Wang Jianzhong J
Medicine 20161101 44
<h4>Background</h4>Steroid therapy has been an important reason of nontraumatic osteonecrosis of the femoral head (ONFH). Steroids are metabolized by hepatic cytochrome P4503A, a low endogenous activity of this enzyme can contribute to the pathogenesis of ONFH. The aim of this study was to investigate the associations of polymorphisms of cytochrome P4503A4 (CYP3A4) gene with steroid-induced ONFH in Chinese patients.<h4>Methods</h4>A total of 150 steroid-induced ONFH patients and 250 healthy cont ...[more]